Reactome | GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

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GAB1 binds phosphatidylinositol-3,4,5-trisphosphate Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:179468] Jassal, B, 2006-05-03 10:36:01
dbId	179467
displayName	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-180292] GAB1 signalosome - Homo sapiens
followingEvent	[Reaction:R-HSA-177941] GRB2:GAB1 binds to phosphorylated EGFR - Homo sapiens
input	[Complex:R-HSA-179849] GRB2:GAB1 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179899] A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
orthologousEvent	[Reaction:R-DME-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Drosophila melanogaster [Reaction:R-GGA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Gallus gallus [Reaction:R-XTR-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Xenopus tropicalis [Reaction:R-SSC-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Sus scrofa [Reaction:R-BTA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Bos taurus [Reaction:R-CFA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Canis familiaris [Reaction:R-RNO-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Rattus norvegicus [Reaction:R-MMU-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Mus musculus
output	[Complex:R-HSA-180282] GRB2:GAB1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Homo sapiens [Reaction:R-HSA-177920] Binding of GRB2 to GAB1 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-179467
summation	[Summation:188541] The pleckstrin homology (PH) domain of GAB1 binds to PIP3 an...
updateTrackers	[UpdateTracker:9789113] Update Tracker - [Reaction:179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - v38:[add_removeInput]

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(updatedInstance)	[UpdateTracker:9789113] Update Tracker - [Reaction:179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - v38:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-180292] GAB1 signalosome
(precedingEvent)	[Reaction:R-HSA-177941] GRB2:GAB1 binds to phosphorylated EGFR