Reactome | Activation of SHP2 through the binding to phospho-Gab1

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Activation of SHP2 through the binding to phospho-Gab1 Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177944
displayName	Activation of SHP2 through the binding to phospho-Gab1
eventOf	[Pathway:R-HSA-180292] GAB1 signalosome - Homo sapiens
figure	[Figure:179428] /figures/phosGAB_SHP2.jpg
followingEvent	[Reaction:R-HSA-177924] Dephosphorylation of Gab1 by SHP2 - Homo sapiens [Reaction:R-HSA-177926] Dephosphorylation of PAG by SHP2 - Homo sapiens [Reaction:R-HSA-177935] SHP2 dephosphorylates Tyr 992 on EGFR - Homo sapiens [Reaction:R-HSA-177923] Sustained activation of SRC kinase by SHP2 - Homo sapiens
input	[Complex:R-HSA-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:180288] Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells [LiteratureReference:180316] Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activation of SHP2 through the binding to phospho-Gab1
orthologousEvent	[Reaction:R-RNO-177944] Activation of SHP2 through the binding to phospho-Gab1 - Rattus norvegicus [Reaction:R-GGA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Gallus gallus [Reaction:R-XTR-177944] Activation of SHP2 through the binding to phospho-Gab1 - Xenopus tropicalis [Reaction:R-SSC-177944] Activation of SHP2 through the binding to phospho-Gab1 - Sus scrofa [Reaction:R-BTA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Bos taurus [Reaction:R-CFA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Canis familiaris [Reaction:R-MMU-177944] Activation of SHP2 through the binding to phospho-Gab1 - Mus musculus
output	[Complex:R-HSA-180269] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-177930] GAB1 phosphorylation by EGFR kinase - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177944
summation	[Summation:180311] The SH2 domains repress phosphatase activity of SHP2. Bindin...

Referrals

(hasEvent)	[Pathway:R-HSA-180292] GAB1 signalosome
(precedingEvent)	[Reaction:R-HSA-177923] Sustained activation of SRC kinase by SHP2 [Reaction:R-HSA-177924] Dephosphorylation of Gab1 by SHP2 [Reaction:R-HSA-177926] Dephosphorylation of PAG by SHP2 [Reaction:R-HSA-177935] SHP2 dephosphorylates Tyr 992 on EGFR