Reactome | Sustained activation of SRC kinase by SHP2

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Sustained activation of SRC kinase by SHP2 Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:180501] non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177923
displayName	Sustained activation of SRC kinase by SHP2
eventOf	[Pathway:R-HSA-180292] GAB1 signalosome - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-180522] p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:180518] A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation [LiteratureReference:180502] Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Sustained activation of SRC kinase by SHP2
orthologousEvent	[Reaction:R-RNO-177923] Sustained activation of SRC kinase by SHP2 - Rattus norvegicus [Reaction:R-GGA-177923] Sustained activation of SRC kinase by SHP2 - Gallus gallus [Reaction:R-SSC-177923] Sustained activation of SRC kinase by SHP2 - Sus scrofa [Reaction:R-BTA-177923] Sustained activation of SRC kinase by SHP2 - Bos taurus [Reaction:R-CFA-177923] Sustained activation of SRC kinase by SHP2 - Canis familiaris [Reaction:R-MMU-177923] Sustained activation of SRC kinase by SHP2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-180499] CSK [plasma membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-180523] PXN:MyrG-SRC [plasma membrane]
precedingEvent	[Reaction:R-HSA-177926] Dephosphorylation of PAG by SHP2 - Homo sapiens [Reaction:R-HSA-177944] Activation of SHP2 through the binding to phospho-Gab1 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177923
summation	[Summation:180519] SHP2 can dephosphorylate paxillin, which leads to CSK dissoc...
updateTrackers	[UpdateTracker:9779933] Update Tracker - [Reaction:177923] Sustained activation of SRC kinase by SHP2 - v64:[addLiteratureReference] [UpdateTracker:9853296] Update Tracker - [Reaction:177923] Sustained activation of SRC kinase by SHP2 - v87:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779933] Update Tracker - [Reaction:177923] Sustained activation of SRC kinase by SHP2 - v64:[addLiteratureReference] [UpdateTracker:9853296] Update Tracker - [Reaction:177923] Sustained activation of SRC kinase by SHP2 - v87:[modifyText]
(hasEvent)	[Pathway:R-HSA-180292] GAB1 signalosome