Reactome | GAB1 signalosome

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GAB1 signalosome Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099493
displayName	GAB1 signalosome
eventOf	[Pathway:R-MMU-177929] Signaling by EGFR - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-177920] Binding of GRB2 to GAB1 - Mus musculus [Reaction:R-MMU-177941] GRB2:GAB1 binds to phosphorylated EGFR - Mus musculus [Reaction:R-MMU-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Mus musculus [Reaction:R-MMU-177930] GAB1 phosphorylation by EGFR kinase - Mus musculus [Reaction:R-MMU-177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - Mus musculus [Reaction:R-MMU-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Mus musculus [Reaction:R-MMU-177944] Activation of SHP2 through the binding to phospho-Gab1 - Mus musculus [Reaction:R-MMU-177924] Dephosphorylation of Gab1 by SHP2 - Mus musculus [Reaction:R-MMU-177935] SHP2 dephosphorylates Tyr 992 on EGFR - Mus musculus [Reaction:R-MMU-177926] Dephosphorylation of PAG by SHP2 - Mus musculus [Reaction:R-MMU-177923] Sustained activation of SRC kinase by SHP2 - Mus musculus
inferredFrom	[Pathway:R-HSA-180292] GAB1 signalosome - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	GAB1 signalosome
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-180292
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-177929] Signaling by EGFR
(inferredTo)	[Pathway:R-HSA-180292] GAB1 signalosome

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