Reactome | DARPP-32 events

DARPP-32 events

Stable Identifier

R-HSA-180024

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation DARPP-32 phosphorylation provides a mechanism for integrating information arriving at dopaminoceptive neurons, in multiple brain regions, via a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones. Activation of PKA or PKG stimulates DARPP-32 phosphorylation at Thr34, converting DARPP-32 into a potent inhibitor of protein phosphatase-1 (PP-1). DARPP-32 is also phosphorylated at Thr75 by Cdk5, converting DARPP-32 into an inhibitor of PKA. Thus, DARPP-32 has the unique property of being a dual-function protein, acting either as an inhibitor of PP-1 or of PKA.

Literature References

PubMed ID	Title	Journal	Year
14744247	DARPP-32: an integrator of neurotransmission Svenningsson, P, Nishi, A, Fisone, G, Girault, JA, Nairn, AC, Greengard, P	Annu Rev Pharmacol Toxicol	2004
2908293	Neuronal phosphoproteins. Mediators of signal transduction Greengard, P	Mol Neurobiol	1987