The pleckstrin homology (PH) domain of GAB1 binds to PIP3 an...

created [InstanceEdit:188528] Jassal, B, 2006-10-17 11:04:33
dbId 188541
displayName The pleckstrin homology (PH) domain of GAB1 binds to PIP3 an...
schemaClass Summation
text The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.
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