The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.
Falasca, M, Rodrigues, GA, Schlessinger, J, Ong, SH, Zhang, Z
© 2022 Reactome