The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.
Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J
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