GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

Stable Identifier
R-HSA-179467
Type
Reaction [binding]
Species
Homo sapiens
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The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.

Literature References
PubMed ID Title Journal Year
10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J

Mol Cell Biol 2000
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