Reactome | GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

Stable Identifier

R-HSA-179467

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

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The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.

Literature References

PubMed ID	Title	Journal	Year
10648629	A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J	Mol Cell Biol	2000