Reactome | GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

Schema > Reaction > Entries

GAB1 binds phosphatidylinositol-3,4,5-trisphosphate Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9999851
displayName	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
eventOf	[Pathway:R-MMU-180292] GAB1 signalosome - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-177941] GRB2:GAB1 binds to phosphorylated EGFR - Mus musculus
inferredFrom	[Reaction:R-HSA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Homo sapiens
input	[Complex:R-MMU-179849] GRB2:GAB1 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
output	[Complex:R-MMU-180282] GRB2:GAB1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-MMU-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Mus musculus [Reaction:R-MMU-177920] Binding of GRB2 to GAB1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-179467
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-180292] GAB1 signalosome
(precedingEvent)	[Reaction:R-MMU-177941] GRB2:GAB1 binds to phosphorylated EGFR
(inferredTo)	[Reaction:R-HSA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

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