Reactome | GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

Schema > Reaction > Entries

GAB1 binds phosphatidylinositol-3,4,5-trisphosphate Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10666939
displayName	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
eventOf	[Pathway:R-DME-180292] GAB1 signalosome - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-DME-177941] GRB2:GAB1 binds to phosphorylated EGFR - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate - Homo sapiens
input	[Complex:R-DME-179849] GRB2:GAB1 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	true
name	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
output	[Complex:R-DME-180282] GRB2:GAB1:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-DME-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Drosophila melanogaster
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-179467
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-180292] GAB1 signalosome
(precedingEvent)	[Reaction:R-DME-177941] GRB2:GAB1 binds to phosphorylated EGFR
(inferredTo)	[Reaction:R-HSA-179467] GAB1 binds phosphatidylinositol-3,4,5-trisphosphate