Reactome | GRB2:SOS1 complex binds to EGF:EGFR complex

Schema > Reaction > Entries

GRB2:SOS1 complex binds to EGF:EGFR complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10840855
displayName	GRB2:SOS1 complex binds to EGF:EGFR complex
eventOf	[Pathway:R-DME-179812] GRB2 events in EGFR signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) - Drosophila melanogaster [Reaction:R-DME-5672965] RAS GEFs promote RAS nucleotide exchange - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Homo sapiens
input	[Complex:R-DME-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Complex:R-DME-109797] GRB2-1:SOS1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GRB2:SOS1 complex binds to EGF:EGFR complex
output	[Complex:R-DME-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-DME-109813] GRB2-1 binds SOS1 - Drosophila melanogaster [Reaction:R-DME-177934] EGFR autophosphorylation - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-177943
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-179812] GRB2 events in EGFR signaling
(precedingEvent)	[Reaction:R-DME-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Reaction:R-DME-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex