Reactome | Phosphorylation of EGFR by SRC kinase

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Phosphorylation of EGFR by SRC kinase Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:179862] protein tyrosine kinase activity of SRC-1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177937
displayName	Phosphorylation of EGFR by SRC kinase
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-177929] Signaling by EGFR - Homo sapiens
figure	[Figure:189925] /figures/egfr_P_by_src.jpg
followingEvent	[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Homo sapiens [Reaction:R-HSA-183055] Binding of CBL to EGFR - Homo sapiens [Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Homo sapiens [Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane - Homo sapiens [Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Homo sapiens [Reaction:R-HSA-177941] GRB2:GAB1 binds to phosphorylated EGFR - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9624420] EGF-like ligands:EGFR dimer [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179802] In vitro phosphorylation of the epidermal growth factor receptor autophosphorylation domain by c-src: identification of phosphorylation sites and c-src SH2 domain binding sites
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of EGFR by SRC kinase
orthologousEvent	[Reaction:R-CEL-177937] Phosphorylation of EGFR by SRC kinase - Caenorhabditis elegans [Reaction:R-GGA-177937] Phosphorylation of EGFR by SRC kinase - Gallus gallus [Reaction:R-XTR-177937] Phosphorylation of EGFR by SRC kinase - Xenopus tropicalis [Reaction:R-DRE-177937] Phosphorylation of EGFR by SRC kinase - Danio rerio [Reaction:R-SSC-177937] Phosphorylation of EGFR by SRC kinase - Sus scrofa [Reaction:R-BTA-177937] Phosphorylation of EGFR by SRC kinase - Bos taurus [Reaction:R-CFA-177937] Phosphorylation of EGFR by SRC kinase - Canis familiaris [Reaction:R-RNO-177937] Phosphorylation of EGFR by SRC kinase - Rattus norvegicus [Reaction:R-MMU-177937] Phosphorylation of EGFR by SRC kinase - Mus musculus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-177922] EGFR dimerization - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:193358] Muthuswamy, S, 2007-02-16 20:08:05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177937
summation	[Summation:188445] Besides autophosphorylation, EGFR can become tyrosine-phosph...
updateTrackers	[UpdateTracker:9789228] Update Tracker - [Reaction:177937] Phosphorylation of EGFR by SRC kinase - v38:[modifyText] [UpdateTracker:9778783] Update Tracker - [Reaction:177937] Phosphorylation of EGFR by SRC kinase - v67:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9789228] Update Tracker - [Reaction:177937] Phosphorylation of EGFR by SRC kinase - v38:[modifyText] [UpdateTracker:9778783] Update Tracker - [Reaction:177937] Phosphorylation of EGFR by SRC kinase - v67:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-177929] Signaling by EGFR
(precedingEvent)	[Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane [Reaction:R-HSA-183055] Binding of CBL to EGFR [Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex [Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor [Reaction:R-HSA-177941] GRB2:GAB1 binds to phosphorylated EGFR

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