Reactome | GRB2:SOS1 complex binds to EGF:EGFR complex

GRB2:SOS1 complex binds to EGF:EGFR complex

Stable Identifier

R-HSA-177943

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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GRB2:SOS1 complex binds to EGF:EGFR complex

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Cytoplasmic target proteins containing the SH2 domain can bind to activated EGFR. One such protein, growth factor receptor-bound protein 2 (GRB2), can bind activated EGFR with its SH2 domain whilst in complex with SOS through its SH3 domain. GRB2 can bind at either Y1092 i.e. Y1068 in the mature protein and/or Y1110 i.e. Y1086 in the mature protein tyrosine autophosphorylation sites on the receptor.

Literature References

PubMed ID	Title	Journal	Year
7518560	Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor Batzer, AG, Rotin, D, Urena, JM, Skolnik, EY, Schlessinger, J	Mol Cell Biol	1994
7527043	Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells Okutani, T, Okabayashi, Y, Kido, Y, Sugimoto, Y, Sakaguchi, K, Matuoka, K, Takenawa, T, Kasuga, M	J Biol Chem	1994