Reactome | SHC1 binds to the phosphorylated EGF receptor:ligand complex

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SHC1 binds to the phosphorylated EGF receptor:ligand complex Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177925
diseaseReaction	[Reaction:R-HSA-5637766] Binding of SHC1 to p-5Y-EGFRvIII - Homo sapiens [Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants - Homo sapiens
displayName	SHC1 binds to the phosphorylated EGF receptor:ligand complex
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling - Homo sapiens
figure	[Figure:179466] /figures/egfr_binds_shc.jpg
followingEvent	[Reaction:R-HSA-177933] SHC1 phosphorylation by phosphorylated EGFR - Homo sapiens
input	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-74680] SHC1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:180339] Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells [LiteratureReference:8933605] The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor [LiteratureReference:8933614] The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SHC1 binds to the phosphorylated EGF receptor:ligand complex
negativePrecedingEvent	[NegativePrecedingEvent:9865822] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
orthologousEvent	[Reaction:R-DME-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Drosophila melanogaster [Reaction:R-GGA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Gallus gallus [Reaction:R-SSC-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Sus scrofa [Reaction:R-BTA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Bos taurus [Reaction:R-CFA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Canis familiaris [Reaction:R-RNO-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Rattus norvegicus [Reaction:R-MMU-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Mus musculus
output	[Complex:R-HSA-9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens [Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177925
summation	[Summation:188529] SHC1 (Src homology 2 domain-containing) transforming protein...
updateTrackers	[UpdateTracker:9782775] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v58:[addLiteratureReference, modifyText] [UpdateTracker:9789470] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v38:[modifyText] [UpdateTracker:9778705] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v67:[add_removeInput, add_removeOutput] [UpdateTracker:9846811] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v84:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782775] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v58:[addLiteratureReference, modifyText] [UpdateTracker:9789470] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v38:[modifyText] [UpdateTracker:9778705] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v67:[add_removeInput, add_removeOutput] [UpdateTracker:9846811] Update Tracker - [Reaction:177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - v84:[modifyText]
(normalReaction)	[Reaction:R-HSA-5637766] Binding of SHC1 to p-5Y-EGFRvIII [Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants
(hasEvent)	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling
(precedingEvent)	[Reaction:R-HSA-177933] SHC1 phosphorylation by phosphorylated EGFR

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