Phosphorylation of EGFR by SRC kinase

Stable Identifier
R-HSA-177937
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of EGFR by SRC kinase
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Besides autophosphorylation, EGFR can become tyrosine-phosphorylated by the action of the proto-oncogene tyrosine-protein kinase, c-src. This Src homology 2 (SH2) domain-containing protein is one of many such proteins which bind to phosphorylated sites on EGFR to affect signal transmission into the cell.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of SRC-1 [plasma membrane]

Physical Entity
SRC-1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of EGFR by SRC kinase (Bos taurus)
Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)
Phosphorylation of EGFR by SRC kinase (Canis familiaris)
Phosphorylation of EGFR by SRC kinase (Danio rerio)
Phosphorylation of EGFR by SRC kinase (Drosophila melanogaster)
Phosphorylation of EGFR by SRC kinase (Gallus gallus)
Phosphorylation of EGFR by SRC kinase (Mus musculus)
Phosphorylation of EGFR by SRC kinase (Rattus norvegicus)
Phosphorylation of EGFR by SRC kinase (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Muthuswamy, S  (2007-02-17)
Created
Jassal, B  (2006-04-11)
Cite Us!