Reactome | Phosphorylation of EGFR by SRC kinase

Schema > Reaction > Entries

Phosphorylation of EGFR by SRC kinase Show undefined attributes

catalystActivity	[CatalystActivity:9999800] protein tyrosine kinase activity of SRC-1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9999802
displayName	Phosphorylation of EGFR by SRC kinase
eventOf	[Pathway:R-MMU-177929] Signaling by EGFR - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Mus musculus [Reaction:R-MMU-183055] Binding of CBL to EGFR - Mus musculus [Reaction:R-MMU-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Mus musculus [Reaction:R-MMU-183067] Localization of CBL:GRB2 to the membrane - Mus musculus [Reaction:R-MMU-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Mus musculus [Reaction:R-MMU-177941] GRB2:GAB1 binds to phosphorylated EGFR - Mus musculus
inferredFrom	[Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-9624420] EGF-like ligands:EGFR dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of EGFR by SRC kinase
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
precedingEvent	[Reaction:R-MMU-177922] EGFR dimerization - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-177937
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-177929] Signaling by EGFR
(precedingEvent)	[Reaction:R-MMU-183067] Localization of CBL:GRB2 to the membrane [Reaction:R-MMU-183055] Binding of CBL to EGFR [Reaction:R-MMU-177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Reaction:R-MMU-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex [Reaction:R-MMU-212706] Phospholipase C-gamma1 binds to the activated EGF receptor [Reaction:R-MMU-177941] GRB2:GAB1 binds to phosphorylated EGFR
(inferredTo)	[Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase