Reactome | Formation of the Flap Intermediate on the C-strand

Schema > Reaction > Entries

Formation of the Flap Intermediate on the C-strand Show undefined attributes

authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
catalystActivity	[CatalystActivity:9668965] 3'-5' DNA helicase activity of BLM,WRN [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
dbId	174438
displayName	Formation of the Flap Intermediate on the C-strand
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
eventOf	[Pathway:R-HSA-174414] Processive synthesis on the C-strand of the telomere - Homo sapiens
followingEvent	[Pathway:R-HSA-174437] Removal of the Flap Intermediate from the C-strand - Homo sapiens [Reaction:R-HSA-174445] RPA binds to the Flap on the C-strand - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-HSA-174435] Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9668969] The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase ? Elongation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Formation of the Flap Intermediate on the C-strand
orthologousEvent	[Reaction:R-GGA-174438] Formation of the Flap Intermediate on the C-strand - Gallus gallus [Reaction:R-SSC-174438] Formation of the Flap Intermediate on the C-strand - Sus scrofa [Reaction:R-BTA-174438] Formation of the Flap Intermediate on the C-strand - Bos taurus [Reaction:R-CFA-174438] Formation of the Flap Intermediate on the C-strand - Canis familiaris [Reaction:R-RNO-174438] Formation of the Flap Intermediate on the C-strand - Rattus norvegicus [Reaction:R-MMU-174438] Formation of the Flap Intermediate on the C-strand - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-174431] Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174444] Formation of C-strand Okazaki fragments - Homo sapiens
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174438
summation	[Summation:9668973] When the polymerase delta:PCNA complex reaches a downstream ...
updateTrackers	[UpdateTracker:9777304] Update Tracker - [Reaction:174438] Formation of the Flap Intermediate on the C-strand - v72:[addCatalystActivity, addInput, addLiteratureReference, addOutput, add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9777304] Update Tracker - [Reaction:174438] Formation of the Flap Intermediate on the C-strand - v72:[addCatalystActivity, addInput, addLiteratureReference, addOutput, add_removeSummation]
(precedingEvent)	[Pathway:R-HSA-174437] Removal of the Flap Intermediate from the C-strand [Reaction:R-HSA-174445] RPA binds to the Flap on the C-strand
(hasEvent)	[Pathway:R-HSA-174414] Processive synthesis on the C-strand of the telomere