Reactome | When the polymerase delta:PCNA complex reaches a downstream ...

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created	[InstanceEdit:9668974] Orlic-Milacic, Marija, 2019-12-02
dbId	9668973
displayName	When the polymerase delta:PCNA complex reaches a downstream ...
literatureReference	[LiteratureReference:69129] DNA polymerase delta holoenzyme: actionon single-starnded DNA and on double-stranded DNA in the presence of replicative DNA helicases. [LiteratureReference:69131] RPA governs endonuclease switching during processing of Okazaki fragments in eucaryotes. [LiteratureReference:69135] Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating nuclear antigen, and flapendonuclease-1. [LiteratureReference:9668969] The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase ? Elongation
modified	[InstanceEdit:9668980] Orlic-Milacic, Marija, 2019-12-02
schemaClass	Summation
text	When the polymerase delta:PCNA complex reaches a downstream Okazaki fragment, strand displacement synthesis occurs. The primer containing 5'-terminus of the downstream Okazaki fragment is folded into a single-stranded flap (Podust et al. 1995, Bae et al. 2001, Maga et al. 2001). The helicase activity of either WRN (Werner syndrome protein) or BLM (Bloom syndrome helicase) is needed for DNA polymerase delta progression and strand displacement synthesis across G-rich telomeric repeats during lagging strand (C-strand) synthesis (Li et al. 2017).

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