Reactome | Formation of the Flap Intermediate on the C-strand

Schema > Reaction > Entries

Formation of the Flap Intermediate on the C-strand Show undefined attributes

catalystActivity	[CatalystActivity:10743728] 3'-5' DNA helicase activity of BLM,WRN [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10743730
displayName	Formation of the Flap Intermediate on the C-strand
eventOf	[Pathway:R-GGA-174414] Processive synthesis on the C-strand of the telomere - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-GGA-174437] Removal of the Flap Intermediate from the C-strand - Gallus gallus [Reaction:R-GGA-174445] RPA binds to the Flap on the C-strand - Gallus gallus
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
inferredFrom	[Reaction:R-HSA-174438] Formation of the Flap Intermediate on the C-strand - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-GGA-174435] Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of the Flap Intermediate on the C-strand
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-GGA-174431] Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm]
precedingEvent	[Reaction:R-GGA-174444] Formation of C-strand Okazaki fragments - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-174438
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-174414] Processive synthesis on the C-strand of the telomere
(precedingEvent)	[Pathway:R-GGA-174437] Removal of the Flap Intermediate from the C-strand [Reaction:R-GGA-174445] RPA binds to the Flap on the C-strand
(inferredTo)	[Reaction:R-HSA-174438] Formation of the Flap Intermediate on the C-strand