Reactome | APC/C:Cdc20 mediated degradation of Securin

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APC/C:Cdc20 mediated degradation of Securin Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
crossReference	[DatabaseIdentifier:12819491] BioModels Database:BIOMD0000000186 [DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819493] BioModels Database:BIOMD0000000187
dbId	174154
displayName	APC/C:Cdc20 mediated degradation of Securin
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
eventOf	[Pathway:R-HSA-176409] APC/C:Cdc20 mediated degradation of mitotic proteins - Homo sapiens
figure	[Figure:177041] /figures/securin.jpg
goBiologicalProcess	[GO_BiologicalProcess:161960] anaphase-promoting complex-dependent catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-174121] Association of Securin with Cdc20:APC/C complex - Homo sapiens [Reaction:R-HSA-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Homo sapiens [BlackBoxEvent:R-HSA-174202] Degradation of multiubiquitinated Securin - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:174096] Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 [LiteratureReference:176919] Splitting the chromosome: cutting the ties that bind sister chromatids
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	APC/C:Cdc20 mediated degradation of Securin
orthologousEvent	[Pathway:R-DDI-174154] APC/C:Cdc20 mediated degradation of Securin - Dictyostelium discoideum [Pathway:R-DME-174154] APC/C:Cdc20 mediated degradation of Securin - Drosophila melanogaster [Pathway:R-GGA-174154] APC/C:Cdc20 mediated degradation of Securin - Gallus gallus [Pathway:R-XTR-174154] APC/C:Cdc20 mediated degradation of Securin - Xenopus tropicalis [Pathway:R-DRE-174154] APC/C:Cdc20 mediated degradation of Securin - Danio rerio [Pathway:R-SSC-174154] APC/C:Cdc20 mediated degradation of Securin - Sus scrofa [Pathway:R-BTA-174154] APC/C:Cdc20 mediated degradation of Securin - Bos taurus [Pathway:R-CFA-174154] APC/C:Cdc20 mediated degradation of Securin - Canis familiaris [Pathway:R-RNO-174154] APC/C:Cdc20 mediated degradation of Securin - Rattus norvegicus [Pathway:R-MMU-174154] APC/C:Cdc20 mediated degradation of Securin - Mus musculus
precedingEvent	[Pathway:R-HSA-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-174154
summation	[Summation:176818] The separation of sister chromatids in anaphase requires the...
updateTrackers	[UpdateTracker:9789355] Update Tracker - [Pathway:174154] APC/C:Cdc20 mediated degradation of Securin - v38:[addLiteratureReference] [UpdateTracker:9787667] Update Tracker - [Pathway:174154] APC/C:Cdc20 mediated degradation of Securin - v44:[updateContainedRLE] [UpdateTracker:9774900] Update Tracker - [Pathway:174154] APC/C:Cdc20 mediated degradation of Securin - v80:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9789355] Update Tracker - [Pathway:174154] APC/C:Cdc20 mediated degradation of Securin - v38:[addLiteratureReference] [UpdateTracker:9787667] Update Tracker - [Pathway:174154] APC/C:Cdc20 mediated degradation of Securin - v44:[updateContainedRLE] [UpdateTracker:9774900] Update Tracker - [Pathway:174154] APC/C:Cdc20 mediated degradation of Securin - v80:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-176409] APC/C:Cdc20 mediated degradation of mitotic proteins

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