Reactome | Association of Securin with Cdc20:APC/C complex

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Association of Securin with Cdc20:APC/C complex Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174121
displayName	Association of Securin with Cdc20:APC/C complex
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
eventOf	[Pathway:R-HSA-174154] APC/C:Cdc20 mediated degradation of Securin - Homo sapiens
followingEvent	[Reaction:R-HSA-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Homo sapiens
input	[Complex:R-HSA-174081] CDC20:p-APC/C [cytosol] [EntityWithAccessionedSequence:R-HSA-174190] PTTG1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:174096] Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Association of Securin with Cdc20:APC/C complex
negativePrecedingEvent	[NegativePrecedingEvent:9764071] Futile Cycle: Degradation of multiubiquitinated Securin [NegativePrecedingEvent:9764142] Futile Cycle: Degradation of multiubiquitinated Cyclin B
orthologousEvent	[Reaction:R-GGA-174121] Association of Securin with Cdc20:APC/C complex - Gallus gallus [Reaction:R-XTR-174121] Association of Securin with Cdc20:APC/C complex - Xenopus tropicalis [Reaction:R-DRE-174121] Association of Securin with Cdc20:APC/C complex - Danio rerio [Reaction:R-SSC-174121] Association of Securin with Cdc20:APC/C complex - Sus scrofa [Reaction:R-BTA-174121] Association of Securin with Cdc20:APC/C complex - Bos taurus [Reaction:R-CFA-174121] Association of Securin with Cdc20:APC/C complex - Canis familiaris [Reaction:R-RNO-174121] Association of Securin with Cdc20:APC/C complex - Rattus norvegicus [Reaction:R-MMU-174121] Association of Securin with Cdc20:APC/C complex - Mus musculus
output	[Complex:R-HSA-174212] CDC20:p-APC/C:PTTG1 [cytosol]
precedingEvent	[Reaction:R-HSA-174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174121
summation	[Summation:176905] Securin is thought to be recognized by the APC/C:Cdc20 compl...

Referrals

(hasEvent)	[Pathway:R-HSA-174154] APC/C:Cdc20 mediated degradation of Securin [Pathway:R-HSA-2467813] Separation of Sister Chromatids
(precedingEvent)	[Reaction:R-HSA-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex