Reactome | APC/C:Cdc20 mediated degradation of Securin

APC/C:Cdc20 mediated degradation of Securin

Stable Identifier

R-HSA-174154

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)

General

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APC/C:Cdc20 mediated degradation of Securin

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The separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohesin subunit, Scc1 that is responsible for the cohesion of sister chromatids (reviewed in Nasmyth et al., 2000). Securin destruction begins at metaphase after the mitotic spindle checkpoint has been satisfied (Hagting et al., 2002).

Literature References

PubMed ID	Title	Journal	Year
10827941	Splitting the chromosome: cutting the ties that bind sister chromatids Uhlmann, F, Nasmyth, K, Peters, JM	Science	2000
12070128	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 Pines, J, Vodermaier, HC, Peters, JM, Den Elzen, N, Hagting, A, Waizenegger, IC	J Cell Biol	2002