Reactome | APC/C:Cdc20 mediated degradation of Securin

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APC/C:Cdc20 mediated degradation of Securin Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222971
displayName	APC/C:Cdc20 mediated degradation of Securin
eventOf	[Pathway:R-RNO-176409] APC/C:Cdc20 mediated degradation of mitotic proteins - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:161960] anaphase-promoting complex-dependent catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-174121] Association of Securin with Cdc20:APC/C complex - Rattus norvegicus [Reaction:R-RNO-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Rattus norvegicus [BlackBoxEvent:R-RNO-174202] Degradation of multiubiquitinated Securin - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-174154] APC/C:Cdc20 mediated degradation of Securin - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	APC/C:Cdc20 mediated degradation of Securin
precedingEvent	[Pathway:R-RNO-174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-174154
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-176409] APC/C:Cdc20 mediated degradation of mitotic proteins
(inferredTo)	[Pathway:R-HSA-174154] APC/C:Cdc20 mediated degradation of Securin

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