Reactome | Ubiquitination of Securin by phospho-APC/C:Cdc20 complex

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Ubiquitination of Securin by phospho-APC/C:Cdc20 complex Show undefined attributes

authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:9764123] ubiquitin-protein transferase activity of CDC20:p-APC/C:PTTG1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174144
displayName	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
eventOf	[Pathway:R-HSA-174154] APC/C:Cdc20 mediated degradation of Securin - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-174202] Degradation of multiubiquitinated Securin - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:7441] ubiquitin-dependent protein catabolic process
input	[Complex:R-HSA-174212] CDC20:p-APC/C:PTTG1 [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:174096] Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 [LiteratureReference:976062] Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex
negativePrecedingEvent	[NegativePrecedingEvent:9764069] Futile Cycle: Degradation of multiubiquitinated Securin [NegativePrecedingEvent:9764080] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764093] Futile Cycle: Degradation of multiubiquitinated Nek2A [NegativePrecedingEvent:9764105] Futile Cycle: Degradation of multiubiquitinated cell cycle proteins [NegativePrecedingEvent:9764113] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9764133] Futile Cycle: Degradation of multiubiquitinated Cyclin B
orthologousEvent	[Reaction:R-DDI-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Dictyostelium discoideum [Reaction:R-DME-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Drosophila melanogaster [Reaction:R-GGA-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Gallus gallus [Reaction:R-XTR-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Xenopus tropicalis [Reaction:R-DRE-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Danio rerio [Reaction:R-SSC-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Sus scrofa [Reaction:R-BTA-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Bos taurus [Reaction:R-CFA-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Canis familiaris [Reaction:R-RNO-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Rattus norvegicus [Reaction:R-MMU-174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - Mus musculus
output	[Complex:R-HSA-3095944] CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol]
precedingEvent	[Reaction:R-HSA-174121] Association of Securin with Cdc20:APC/C complex - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174144
summation	[Summation:176912] Securin is ubiquitinated by APC/C:Cdc20 (Hagting et al., 200...
updateTrackers	[UpdateTracker:9787651] Update Tracker - [Reaction:174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - v44:[addLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9774880] Update Tracker - [Reaction:174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - v80:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9787651] Update Tracker - [Reaction:174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - v44:[addLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9774880] Update Tracker - [Reaction:174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex - v80:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-174154] APC/C:Cdc20 mediated degradation of Securin [Pathway:R-HSA-2467813] Separation of Sister Chromatids
(precedingEvent)	[BlackBoxEvent:R-HSA-174202] Degradation of multiubiquitinated Securin

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