Reactome | Signaling by TGF-beta Receptor Complex

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Signaling by TGF-beta Receptor Complex Show undefined attributes

authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
created	[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
dbId	170834
diseasePathways	[Pathway:R-HSA-3642279] TGFBR2 MSI Frameshift Mutants in Cancer - Homo sapiens [Pathway:R-HSA-3645790] TGFBR2 Kinase Domain Mutants in Cancer - Homo sapiens [Pathway:R-HSA-3656535] TGFBR1 LBD Mutants in Cancer - Homo sapiens [Pathway:R-HSA-3656532] TGFBR1 KD Mutants in Cancer - Homo sapiens [Pathway:R-HSA-3311021] SMAD4 MH2 Domain Mutants in Cancer - Homo sapiens [Pathway:R-HSA-3304356] SMAD2/3 Phosphorylation Motif Mutants in Cancer - Homo sapiens [Pathway:R-HSA-3315487] SMAD2/3 MH2 Domain Mutants in Cancer - Homo sapiens
displayName	Signaling by TGF-beta Receptor Complex
edited	[InstanceEdit:178162] Jassal, B, 2006-04-18 13:31:36 [InstanceEdit:2187413] Jassal, B, 2012-04-10
eventOf	[Pathway:R-HSA-9006936] Signaling by TGFB family members - Homo sapiens
figure	[Figure:1996285] /figures/Pathway_Illustrations/TGFb_72_oicr.png
goBiologicalProcess	[GO_BiologicalProcess:19282] transforming growth factor beta receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-2173789] TGF-beta receptor signaling activates SMADs - Homo sapiens [Pathway:R-HSA-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) - Homo sapiens [Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:1497896] New regulatory mechanisms of TGF-beta receptor function
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Signaling by TGF-beta Receptor Complex Transforming Growth Factor (TGF) beta signaling
orthologousEvent	[Pathway:R-MMU-170834] Signaling by TGF-beta Receptor Complex - Mus musculus [Pathway:R-RNO-170834] Signaling by TGF-beta Receptor Complex - Rattus norvegicus [Pathway:R-CFA-170834] Signaling by TGF-beta Receptor Complex - Canis familiaris [Pathway:R-BTA-170834] Signaling by TGF-beta Receptor Complex - Bos taurus [Pathway:R-SSC-170834] Signaling by TGF-beta Receptor Complex - Sus scrofa [Pathway:R-DRE-170834] Signaling by TGF-beta Receptor Complex - Danio rerio [Pathway:R-XTR-170834] Signaling by TGF-beta Receptor Complex - Xenopus tropicalis [Pathway:R-GGA-170834] Signaling by TGF-beta Receptor Complex - Gallus gallus [Pathway:R-DME-170834] Signaling by TGF-beta Receptor Complex - Drosophila melanogaster [Pathway:R-CEL-170834] Signaling by TGF-beta Receptor Complex - Caenorhabditis elegans [Pathway:R-DDI-170834] Signaling by TGF-beta Receptor Complex - Dictyostelium discoideum [Pathway:R-SPO-170834] Signaling by TGF-beta Receptor Complex - Schizosaccharomyces pombe [Pathway:R-SCE-170834] Signaling by TGF-beta Receptor Complex - Saccharomyces cerevisiae [Pathway:R-PFA-170834] Signaling by TGF-beta Receptor Complex - Plasmodium falciparum
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12 [InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
revised	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-170834
summation	[Summation:171269] The TGF-beta/BMP pathway incorporates several signaling path...
updateTrackers	[UpdateTracker:9842349] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v86:[updateIndirectRLE] [UpdateTracker:9788960] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v39:[updateContainedRLE] [UpdateTracker:9792147] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v23:[updateContainedRLE] [UpdateTracker:9775485] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v79:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789353] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v38:[modifyText, updateContainedRLE] [UpdateTracker:9788161] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v43:[updateIndirectRLE] [UpdateTracker:9787682] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v44:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791780] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v26:[modifyText] [UpdateTracker:9789737] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v37:[updateContainedRLE] [UpdateTracker:9788508] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v41:[addLiteratureReference, add_removeHasEvent, modifyText] [UpdateTracker:9774688] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v81:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777366] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v72:[updateIndirectRLE] [UpdateTracker:9775264] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v80:[updateIndirectRLE] [UpdateTracker:9787233] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v46:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9785229] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v52:[updateContainedPathway] [UpdateTracker:9781836] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v60:[updateIndirectRLE] [UpdateTracker:9792516] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v20:[updateContainedRLE] [UpdateTracker:9775548] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v78:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-9006936] Signaling by TGFB family members
(hasEncapsulatedEvent)	[Pathway:R-HSA-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer [Pathway:R-HSA-1980143] Signaling by NOTCH1 [Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3 [Pathway:R-HSA-9617828] FOXO-mediated transcription of cell cycle genes [Pathway:R-HSA-9692914] SARS-CoV-1-host interactions [Pathway:R-HSA-9839373] Signaling by TGFBR3
(normalPathway)	[Pathway:R-HSA-3642279] TGFBR2 MSI Frameshift Mutants in Cancer [Pathway:R-HSA-3645790] TGFBR2 Kinase Domain Mutants in Cancer [Pathway:R-HSA-3656535] TGFBR1 LBD Mutants in Cancer [Pathway:R-HSA-3656532] TGFBR1 KD Mutants in Cancer [Pathway:R-HSA-3311021] SMAD4 MH2 Domain Mutants in Cancer [Pathway:R-HSA-3304356] SMAD2/3 Phosphorylation Motif Mutants in Cancer [Pathway:R-HSA-3315487] SMAD2/3 MH2 Domain Mutants in Cancer
(updatedInstance)	[UpdateTracker:9842349] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v86:[updateIndirectRLE] [UpdateTracker:9788960] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v39:[updateContainedRLE] [UpdateTracker:9792147] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v23:[updateContainedRLE] [UpdateTracker:9775485] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v79:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789353] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v38:[modifyText, updateContainedRLE] [UpdateTracker:9788161] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v43:[updateIndirectRLE] [UpdateTracker:9787682] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v44:[modifyText, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791780] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v26:[modifyText] [UpdateTracker:9789737] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v37:[updateContainedRLE] [UpdateTracker:9788508] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v41:[addLiteratureReference, add_removeHasEvent, modifyText] [UpdateTracker:9774688] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v81:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9777366] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v72:[updateIndirectRLE] [UpdateTracker:9775264] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v80:[updateIndirectRLE] [UpdateTracker:9787233] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v46:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9785229] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v52:[updateContainedPathway] [UpdateTracker:9781836] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v60:[updateIndirectRLE] [UpdateTracker:9792516] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v20:[updateContainedRLE] [UpdateTracker:9775548] Update Tracker - [Pathway:170834] Signaling by TGF-beta Receptor Complex - v78:[updateContainedPathway, updateIndirectRLE]

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