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Entries
SMAD2/3 MH2 Domain Mutants in Cancer
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authored
[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08
[InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08
[InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
created
[InstanceEdit:3315489] Orlic-Milacic, M, 2013-04-25
crossReference
[DatabaseIdentifier:12819607] BioModels Database:BIOMD0000000997
[DatabaseIdentifier:12020745] Mondo:0004992
[DatabaseIdentifier:12819609] BioModels Database:BIOMD0000000342
[DatabaseIdentifier:12819611] BioModels Database:BIOMD0000001001
[DatabaseIdentifier:12819613] BioModels Database:BIOMD0000001003
[DatabaseIdentifier:12819615] BioModels Database:BIOMD0000000989
[DatabaseIdentifier:12819617] BioModels Database:BIOMD0000000499
[DatabaseIdentifier:12819619] BioModels Database:BIOMD0000000995
[DatabaseIdentifier:12819621] BioModels Database:BIOMD0000000173
[DatabaseIdentifier:12819623] BioModels Database:BIOMD0000000998
[DatabaseIdentifier:12819625] BioModels Database:BIOMD0000000996
[DatabaseIdentifier:12819627] BioModels Database:BIOMD0000000990
[DatabaseIdentifier:12819629] BioModels Database:BIOMD0000001000
[DatabaseIdentifier:12819631] BioModels Database:BIOMD0000000999
[DatabaseIdentifier:12819635] BioModels Database:BIOMD0000001002
[DatabaseIdentifier:12819637] BioModels Database:BIOMD0000000994
dbId
3315487
disease
[Disease:1500689] cancer
displayName
SMAD2/3 MH2 Domain Mutants in Cancer
edited
[InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
[InstanceEdit:3322153] Jassal, Bijay, 2013-05-03
eventOf
[Pathway:R-HSA-3304349] Loss of Function of SMAD2/3 in Cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[FailedReaction:R-HSA-3315483] Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2019-03-25
literatureReference
[LiteratureReference:3304374] SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer
maxDepth
2
modified
[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name
SMAD2/3 MH2 Domain Mutants in Cancer
normalPathway
[Pathway:R-HSA-170834] Signaling by TGF-beta Receptor Complex
releaseDate
2013-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08
[InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-3315487
summation
[Summation:3318507] Mutations in the MH2 domain of SMAD2 and SMAD3 affect their ...
updateTrackers
[UpdateTracker:9778540] Update Tracker - [Pathway:3315487] SMAD2/3 MH2 Domain Mutants in Cancer - v68:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9785431] Update Tracker - [Pathway:3315487] SMAD2/3 MH2 Domain Mutants in Cancer - v52:[removeHasEvent]
Referrals
(updatedInstance)
[UpdateTracker:9778540] Update Tracker - [Pathway:3315487] SMAD2/3 MH2 Domain Mutants in Cancer - v68:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9785431] Update Tracker - [Pathway:3315487] SMAD2/3 MH2 Domain Mutants in Cancer - v52:[removeHasEvent]
(hasEvent)
[Pathway:R-HSA-3304349] Loss of Function of SMAD2/3 in Cancer
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