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Transcriptional regulation by RUNX3
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authored
[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
created
[InstanceEdit:8878158] Orlic-Milacic, Marija, 2016-06-30
dbId
8878159
displayName
Transcriptional regulation by RUNX3
doi
10.3180/R-HSA-8878159.1
edited
[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf
[Pathway:R-HSA-212436] Generic Transcription Pathway - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-8941858] Regulation of RUNX3 expression and activity - Homo sapiens
[Pathway:R-HSA-8941855] RUNX3 regulates CDKN1A transcription - Homo sapiens
[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling - Homo sapiens
[Pathway:R-HSA-8949275] RUNX3 Regulates Immune Response and Cell Migration - Homo sapiens
[Pathway:R-HSA-8951430] RUNX3 regulates WNT signaling - Homo sapiens
[Pathway:R-HSA-8951671] RUNX3 regulates YAP1-mediated transcription - Homo sapiens
[Pathway:R-HSA-8951911] RUNX3 regulates RUNX1-mediated transcription - Homo sapiens
[Pathway:R-HSA-8951936] RUNX3 regulates p14-ARF - Homo sapiens
[Pathway:R-HSA-8952158] RUNX3 regulates BCL2L11 (BIM) transcription - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8941759] Runx3-regulated expression of two Ntrk3 transcript variants in dorsal root ganglion neurons
[LiteratureReference:8941775] Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation
[LiteratureReference:8941770] The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling
[LiteratureReference:8941786] A novel HMM-based method for detecting enriched transcription factor binding sites reveals RUNX3 as a potential target in pancreatic cancer biology
[LiteratureReference:8941792] The human CD6 gene is transcriptionally regulated by RUNX and Ets transcription factors in T cells
[LiteratureReference:8941798] Dynamic regulation of the expression of neurotrophin receptors by Runx3
[LiteratureReference:8941803] Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver
[LiteratureReference:8941823] Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk
[LiteratureReference:8941833] CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin
[LiteratureReference:8865447] Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons
[LiteratureReference:8878139] RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD
[LiteratureReference:8878203] Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling
[LiteratureReference:8878223] RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
[LiteratureReference:8949123] A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
[LiteratureReference:8949254] Runx3 specifies lineage commitment of innate lymphoid cells
[LiteratureReference:8949257] RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters
[LiteratureReference:8949262] Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4? T cell immunity
[LiteratureReference:8949273] Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation
[LiteratureReference:8949440] Causal relationship between the loss of RUNX3 expression and gastric cancer
[LiteratureReference:8949469] RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer
[LiteratureReference:8949452] CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
[LiteratureReference:8949450] RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking
[LiteratureReference:8951545] RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer
[LiteratureReference:8951904] RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor ?
[LiteratureReference:8952434] RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma
[LiteratureReference:8952853] The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
Transcriptional regulation by RUNX3
orthologousEvent
[Pathway:R-MMU-8878159] Transcriptional regulation by RUNX3 - Mus musculus
[Pathway:R-RNO-8878159] Transcriptional regulation by RUNX3 - Rattus norvegicus
[Pathway:R-CFA-8878159] Transcriptional regulation by RUNX3 - Canis familiaris
[Pathway:R-BTA-8878159] Transcriptional regulation by RUNX3 - Bos taurus
[Pathway:R-SSC-8878159] Transcriptional regulation by RUNX3 - Sus scrofa
[Pathway:R-DRE-8878159] Transcriptional regulation by RUNX3 - Danio rerio
[Pathway:R-GGA-8878159] Transcriptional regulation by RUNX3 - Gallus gallus
[Pathway:R-DME-8878159] Transcriptional regulation by RUNX3 - Drosophila melanogaster
[Pathway:R-CEL-8878159] Transcriptional regulation by RUNX3 - Caenorhabditis elegans
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31
[InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8878159
summation
[Summation:8941758] The transcription factor RUNX3 is a RUNX family member. All ...
Referrals
(hasEvent)
[Pathway:R-HSA-212436] Generic Transcription Pathway
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