Reactome | TGFBR2 Kinase Domain Mutants in Cancer

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TGFBR2 Kinase Domain Mutants in Cancer Show undefined attributes

authored	[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08 [InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08 [InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
created	[InstanceEdit:3645789] Orlic-Milacic, M, 2013-05-30
crossReference	[DatabaseIdentifier:12819605] BioModels Database:BIOMD0000000791 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819607] BioModels Database:BIOMD0000000997 [DatabaseIdentifier:12819609] BioModels Database:BIOMD0000000342 [DatabaseIdentifier:12819611] BioModels Database:BIOMD0000001001 [DatabaseIdentifier:12819613] BioModels Database:BIOMD0000001003 [DatabaseIdentifier:12819615] BioModels Database:BIOMD0000000989 [DatabaseIdentifier:12819617] BioModels Database:BIOMD0000000499 [DatabaseIdentifier:12819619] BioModels Database:BIOMD0000000995 [DatabaseIdentifier:12819621] BioModels Database:BIOMD0000000173 [DatabaseIdentifier:12819623] BioModels Database:BIOMD0000000998 [DatabaseIdentifier:12819625] BioModels Database:BIOMD0000000996 [DatabaseIdentifier:12819627] BioModels Database:BIOMD0000000990 [DatabaseIdentifier:12819629] BioModels Database:BIOMD0000001000 [DatabaseIdentifier:12819631] BioModels Database:BIOMD0000000999 [DatabaseIdentifier:12819633] BioModels Database:BIOMD0000000757 [DatabaseIdentifier:12819635] BioModels Database:BIOMD0000001002 [DatabaseIdentifier:12819637] BioModels Database:BIOMD0000000994
dbId	3645790
disease	[Disease:1500689] cancer
displayName	TGFBR2 Kinase Domain Mutants in Cancer
edited	[InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
eventOf	[Pathway:R-HSA-3642278] Loss of Function of TGFBR2 in Cancer - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-3645780] TGFBR2 KD mutants do not phosphorylate TGFBR1 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:3640895] Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers [LiteratureReference:3645769] A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma [LiteratureReference:3318552] Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer [LiteratureReference:3654162] Mutation analysis of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and intron primers
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	TGFBR2 Kinase Domain Mutants in Cancer
normalPathway	[Pathway:R-HSA-170834] Signaling by TGF-beta Receptor Complex
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08 [InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3645790
summation	[Summation:3654163] Missense mutations in the kinase domain (KD) of TGF-beta rec...
updateTrackers	[UpdateTracker:9778376] Update Tracker - [Pathway:3645790] TGFBR2 Kinase Domain Mutants in Cancer - v68:[removeHasEvent, updateContainedRLE] [UpdateTracker:9785056] Update Tracker - [Pathway:3645790] TGFBR2 Kinase Domain Mutants in Cancer - v52:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9778376] Update Tracker - [Pathway:3645790] TGFBR2 Kinase Domain Mutants in Cancer - v68:[removeHasEvent, updateContainedRLE] [UpdateTracker:9785056] Update Tracker - [Pathway:3645790] TGFBR2 Kinase Domain Mutants in Cancer - v52:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-3642278] Loss of Function of TGFBR2 in Cancer

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