Reactome | Signaling by TGF-beta Receptor Complex

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Signaling by TGF-beta Receptor Complex Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729208
displayName	Signaling by TGF-beta Receptor Complex
eventOf	[Pathway:R-XTR-9006936] Signaling by TGFB family members - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19282] transforming growth factor beta receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-XTR-2173789] TGF-beta receptor signaling activates SMADs - Xenopus tropicalis [Pathway:R-XTR-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) - Xenopus tropicalis [Pathway:R-XTR-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-170834] Signaling by TGF-beta Receptor Complex - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	4
name	Signaling by TGF-beta Receptor Complex Transforming Growth Factor (TGF) beta signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-170834
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9006936] Signaling by TGFB family members
(hasEncapsulatedEvent)	[Pathway:R-XTR-9839373] Signaling by TGFBR3 [Pathway:R-XTR-9617828] FOXO-mediated transcription of cell cycle genes [Pathway:R-XTR-8878159] Transcriptional regulation by RUNX3 [Pathway:R-XTR-1980143] Signaling by NOTCH1 [Pathway:R-XTR-2173793] Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
(inferredTo)	[Pathway:R-HSA-170834] Signaling by TGF-beta Receptor Complex

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