Reactome | Toll Like Receptor 7/8 (TLR7/8) Cascade

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Toll Like Receptor 7/8 (TLR7/8) Cascade Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099309
displayName	Toll Like Receptor 7/8 (TLR7/8) Cascade
eventOf	[Pathway:R-MMU-168898] Toll-like Receptor Cascades - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:258822] toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-9679029] C-ter TLR7 dimer binds HCQ - Mus musculus [Reaction:R-MMU-9724670] C-ter TLR7 dimer binds imiquimod - Mus musculus [Pathway:R-MMU-975155] MyD88 dependent cascade initiated on endosome - Mus musculus [Pathway:R-MMU-9860276] SLC15A4:TASL-dependent IRF5 activation - Mus musculus
inferredFrom	[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	8
name	Toll Like Receptor 7/8 (TLR7/8) Cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-168181
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-168898] Toll-like Receptor Cascades
(inferredTo)	[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade

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