Reactome | C-ter TLR7 dimer binds imiquimod

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C-ter TLR7 dimer binds imiquimod Show undefined attributes

authored	[InstanceEdit:9716631] Stephan, Ralf, 2021-02-23
category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
dbId	9724670
definition	Agonist
displayName	C-ter TLR7 dimer binds imiquimod
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 - Homo sapiens
input	[Complex:R-HSA-1679575] C-ter TLR7 dimer [endosome membrane] [ChemicalDrug:R-ALL-9724672] imiquimod [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9724664] Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8 [LiteratureReference:9724892] Imiquimod applied topically: a novel immune response modifier and new class of drug [LiteratureReference:9724890] Beyond a decade of 5% imiquimod topical therapy [LiteratureReference:9724904] Imiquimod in dermatology: an overview
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	C-ter TLR7 dimer binds imiquimod
orthologousEvent	[Reaction:R-GGA-9724670] C-ter TLR7 dimer binds imiquimod - Gallus gallus [Reaction:R-XTR-9724670] C-ter TLR7 dimer binds imiquimod - Xenopus tropicalis [Reaction:R-SSC-9724670] C-ter TLR7 dimer binds imiquimod - Sus scrofa [Reaction:R-BTA-9724670] C-ter TLR7 dimer binds imiquimod - Bos taurus [Reaction:R-CFA-9724670] C-ter TLR7 dimer binds imiquimod - Canis familiaris [Reaction:R-RNO-9724670] C-ter TLR7 dimer binds imiquimod - Rattus norvegicus [Reaction:R-MMU-9724670] C-ter TLR7 dimer binds imiquimod - Mus musculus
output	[Complex:R-HSA-9724662] C-ter TLR7 dimer:imiquimod [endosome membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9724670
summation	[Summation:9724894] Activation of toll-like receptor 7 (TLR7) leads to secretion...

Referrals

(hasEvent)	[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade
(precedingEvent)	[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9