Reactome | Phosphorylated MAPKs phosphorylate ATF-2

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Phosphorylated MAPKs phosphorylate ATF-2 Show undefined attributes

catalystActivity	[CatalystActivity:10571366] protein serine/threonine kinase activity of Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10571368
displayName	Phosphorylated MAPKs phosphorylate ATF-2
eventOf	[Pathway:R-GGA-450341] Activation of the AP-1 family of transcription factors - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. - Gallus gallus
inferredFrom	[Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-GGA-450336] ATF2 [nucleoplasm] 2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
isInDisease	false
isInferred	true
name	Phosphorylated MAPKs phosphorylate ATF-2
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-GGA-450243] phospho-p-T69,T71-ATF2 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-450348] Activated human JNKs migrate to nucleoplasm - Gallus gallus [Reaction:R-GGA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus [BlackBoxEvent:R-GGA-5674387] Phosphorylated MAPKs translocate into the nucleus - Gallus gallus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-168053
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-450341] Activation of the AP-1 family of transcription factors
(precedingEvent)	[Reaction:R-GGA-168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
(inferredTo)	[Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2