Reactome | Nef Mediated CD4 Down-regulation

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Nef Mediated CD4 Down-regulation Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
created	[InstanceEdit:167538] Gillespie, ME, 2005-10-20 18:11:21
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	167590
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nef Mediated CD4 Down-regulation
eventOf	[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160451] negative regulation of defense response to virus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-167566] Nef mediated disruption of CD4:Lck Complex - Homo sapiens [Reaction:R-HSA-167537] Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex - Homo sapiens [Reaction:R-HSA-167597] Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex - Homo sapiens [Reaction:R-HSA-200879] Formation of a Nef:ARF1:CD4 complex - Homo sapiens [BlackBoxEvent:R-HSA-167601] Degradation of CD4 - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2013-03-31
literatureReference	[LiteratureReference:200888] Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain [LiteratureReference:182238] Serine phosphorylation-independent downregulation of cell-surface CD4 by nef [LiteratureReference:200885] Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail [LiteratureReference:167574] Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain [LiteratureReference:200880] The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.
maxDepth	2
modified	[InstanceEdit:9953542] Gillespie, Marc E, 2025-06-03
name	Nef Mediated CD4 Down-regulation
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-167590
summation	[Summation:167557] The presence of Nef accelerates endocytosis and lysosomal de...
updateTrackers	[UpdateTracker:9787925] Update Tracker - [Pathway:167590] Nef Mediated CD4 Down-regulation - v44:[updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9787925] Update Tracker - [Pathway:167590] Nef Mediated CD4 Down-regulation - v44:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters