Reactome | Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex

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Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:167538] Gillespie, ME, 2005-10-20 18:11:21
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	167597
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
eventOf	[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-182171] Degradation of CD8 - Homo sapiens [BlackBoxEvent:R-HSA-167601] Degradation of CD4 - Homo sapiens
input	[Complex:R-HSA-167544] CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:182238] Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
output	[Complex:R-HSA-167554] Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane]
precedingEvent	[Reaction:R-HSA-167537] Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-167597
summation	[Summation:201385] The Nef:CD4:AP-2 complex is internalized

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-182171] Degradation of CD8 [BlackBoxEvent:R-HSA-167601] Degradation of CD4
(hasEvent)	[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation

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