Reactome | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Schema > Pathway > Entries

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Show undefined attributes

authored	[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
created	[InstanceEdit:164941] Gillespie, ME, 2005-07-22 21:03:59
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	164938
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
eventOf	[Pathway:R-HSA-164952] The role of Nef in HIV-1 replication and disease pathogenesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:160451] negative regulation of defense response to virus
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-164939] Nef mediated downregulation of CD28 cell surface expression - Homo sapiens [Pathway:R-HSA-164940] Nef mediated downregulation of MHC class I complex cell surface expression - Homo sapiens [Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation - Homo sapiens [Pathway:R-HSA-182218] Nef Mediated CD8 Down-regulation - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2013-03-31
literatureReference	[LiteratureReference:182247] HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes [LiteratureReference:200836] A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor [LiteratureReference:200901] A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4 [LiteratureReference:200827] Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation [LiteratureReference:200884] Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity [LiteratureReference:200882] Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes [LiteratureReference:200839] Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules [LiteratureReference:200878] Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex
maxDepth	3
modified	[InstanceEdit:9953542] Gillespie, Marc E, 2025-06-03
name	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-164938
summation	[Summation:182287] The maximal virulence of HIV-1 requires Nef, a virally encod...
updateTrackers	[UpdateTracker:9788044] Update Tracker - [Pathway:164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters - v44:[updateIndirectRLE]

Referrals

(updatedInstance)	[UpdateTracker:9788044] Update Tracker - [Pathway:164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters - v44:[updateIndirectRLE]
(hasEvent)	[Pathway:R-HSA-164952] The role of Nef in HIV-1 replication and disease pathogenesis