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Entries
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
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authored
[InstanceEdit:200905] Gillespie, ME, 2007-07-25 19:42:36
created
[InstanceEdit:164941] Gillespie, ME, 2005-07-22 21:03:59
dbId
164938
disease
[Disease:1660559] Human immunodeficiency virus infectious disease
displayName
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
eventOf
[Pathway:R-HSA-164952] The role of Nef in HIV-1 replication and disease pathogenesis - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:6537] mitigation of host antiviral defense response
hasDiagram
false
hasEHLD
false
hasEvent
[Pathway:R-HSA-164939] Nef mediated downregulation of CD28 cell surface expression - Homo sapiens
[Pathway:R-HSA-164940] Nef mediated downregulation of MHC class I complex cell surface expression - Homo sapiens
[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation - Homo sapiens
[Pathway:R-HSA-182218] Nef Mediated CD8 Down-regulation - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:182247] HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes
[LiteratureReference:200836] A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
[LiteratureReference:200901] A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
[LiteratureReference:200827] Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
[LiteratureReference:200884] Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
[LiteratureReference:200882] Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes
[LiteratureReference:200839] Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
[LiteratureReference:200878] Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex
modified
[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
relatedSpecies
[Species:164493] Human immunodeficiency virus 1
releaseDate
2007-08-21
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:201388] Skowronski, J, 2007-08-07 14:33:41
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-164938
summation
[Summation:182287] The maximal virulence of HIV-1 requires Nef, a virally encod...
Referrals
(hasEvent)
[Pathway:R-HSA-164952] The role of Nef in HIV-1 replication and disease pathogenesis
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