Reactome | PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

Stable Identifier

R-HSA-1675773

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

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At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3). This is a minor reaction, however, and its physiological role is uncertain.

The following lists the above proteins with their corresponding literature references: PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002, Krauss et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
9660759	Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate Tolias, KF, Rameh, LE, Ishihara, H, Shibasaki, Y, Chen, J, Prestwich, GD, Cantley, LC, Carpenter, CL	J Biol Chem	1998
9211928	Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules Zhang, X, Loijens, JC, Boronenkov, IV, Parker, GJ, Norris, FA, Chen, J, Thum, O, Prestwich, GD, Majerus, PW, Anderson, RA	J Biol Chem	1997
12847086	ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma Krauss, M, Kinuta, M, Wenk, MR, De Camilli, P, Takei, K, Haucke, V	J Cell Biol	2003
12422219	Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Di Paolo, G, Pellegrini, L, Letinic, K, Cestra, G, Zoncu, R, Voronov, S, Chang, S, Guo, J, Wenk, MR, De Camilli, P	Nature	2002
11604140	PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse Wenk, MR, Pellegrini, L, Klenchin, VA, Di Paolo, G, Chang, S, Daniell, L, Arioka, M, Martin, TF, De Camilli, P	Neuron	2001