PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3). This is a minor reaction, however, and its physiological role is uncertain.

The following lists the above proteins with their corresponding literature references: PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002, Krauss et al. 2003).
Literature References
PubMed ID Title Journal Year
9211928 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

Thum, O, Majerus, PW, Parker, GJ, Boronenkov, IV, Zhang, X, Prestwich, GD, Anderson, RA, Loijens, JC, Chen, J, Norris, FA

J Biol Chem 1997
9660759 Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

Rameh, LE, Cantley, LC, Ishihara, H, Shibasaki, Y, Prestwich, GD, Carpenter, CL, Chen, J, Tolias, KF

J Biol Chem 1998
12847086 ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma

Kinuta, M, Krauss, M, Haucke, V, Wenk, MR, Takei, K, De Camilli, P

J Cell Biol 2003
12422219 Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

Cestra, G, Pellegrini, L, Di Paolo, G, Zoncu, R, Letinic, K, Wenk, MR, Voronov, S, De Camilli, P, Guo, J, Chang, S

Nature 2002
11604140 PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse

Daniell, L, Di Paolo, G, Pellegrini, L, Arioka, M, Martin, TF, Wenk, MR, De Camilli, P, Chang, S, Klenchin, VA

Neuron 2001
Catalyst Activity

phosphatidylinositol kinase activity of PIP5K1A-C [cytosol]

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