Reactome | PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

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PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane Show undefined attributes

catalystActivity	[CatalystActivity:10774100] phosphatidylinositol kinase activity of PIP5K1A-C [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10774102
displayName	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
eventOf	[Pathway:R-GGA-1660499] Synthesis of PIPs at the plasma membrane - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Gallus gallus [Reaction:R-GGA-199456] PTEN dephosphorylates PIP3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-GGA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane - Gallus gallus [Reaction:R-GGA-1676109] PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane - Gallus gallus [Reaction:R-GGA-1676145] PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-1675773
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1660499] Synthesis of PIPs at the plasma membrane
(precedingEvent)	[Reaction:R-GGA-199456] PTEN dephosphorylates PIP3 [Reaction:R-GGA-1675949] PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane
(inferredTo)	[Reaction:R-HSA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane

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