Reactome | Formation of HIV-1 elongation complex containing HIV-1 Tat

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Formation of HIV-1 elongation complex containing HIV-1 Tat Show undefined attributes

authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167201] Matthews, L, 2005-10-12 16:55:39
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	167200
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Formation of HIV-1 elongation complex containing HIV-1 Tat
edited	[InstanceEdit:165066] Matthews, L, 2005-07-26 23:29:22
eventOf	[Pathway:R-HSA-167246] Tat-mediated elongation of the HIV-1 transcript - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-167234] Association of Tat with P-TEFb(Cyclin T1:Cdk9) - Homo sapiens [Reaction:R-HSA-167191] Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex - Homo sapiens [Reaction:R-HSA-170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex - Homo sapiens [Reaction:R-HSA-170704] Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex - Homo sapiens [Reaction:R-HSA-167196] Recruitment of elongation factors to form HIV-1 elongation complex - Homo sapiens
inferredFrom	[Pathway:R-HSA-112382] Formation of RNA Pol II elongation complex - Homo sapiens
isInDisease	true
isInferred	true
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:167873] A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA [LiteratureReference:170755] Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription [LiteratureReference:170767] Domains in the SPT5 protein that modulate its transcriptional regulatory properties [LiteratureReference:170711] Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element [LiteratureReference:170692] Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Formation of HIV-1 elongation complex containing HIV-1 Tat
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-167200
summation	[Summation:167882] This HIV-1 event was inferred from the corresponding human R...
updateTrackers	[UpdateTracker:9787533] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v44:[updateContainedRLE] [UpdateTracker:9789149] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v38:[addLiteratureReference] [UpdateTracker:9784377] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v54:[updateContainedRLE] [UpdateTracker:9775165] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v80:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9787533] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v44:[updateContainedRLE] [UpdateTracker:9789149] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v38:[addLiteratureReference] [UpdateTracker:9784377] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v54:[updateContainedRLE] [UpdateTracker:9775165] Update Tracker - [Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - v80:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-167246] Tat-mediated elongation of the HIV-1 transcript
(inferredTo)	[Pathway:R-HSA-112382] Formation of RNA Pol II elongation complex

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