Reactome | Tat-mediated elongation of the HIV-1 transcript

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Tat-mediated elongation of the HIV-1 transcript Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167247] Matthews, L, 2005-10-13 20:45:52
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	167246
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Tat-mediated elongation of the HIV-1 transcript
eventOf	[Pathway:R-HSA-167169] HIV Transcription Elongation - Homo sapiens
figure	[Figure:167487] /figures/TAT_mediated_Elong.jpg
goBiologicalProcess	[GO_BiologicalProcess:80812] positive regulation of viral transcription
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - Homo sapiens [Reaction:R-HSA-167181] Addition of nucleotides leads to HIV-1 transcript elongation - Homo sapiens [Reaction:R-HSA-167192] Pol II elongation complex moves on the HIV-1 template as transcript elongates - Homo sapiens [Reaction:R-HSA-167197] Separation of elongating HIV-1 transcript from template - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:170749] A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation [LiteratureReference:167873] A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA [LiteratureReference:170634] Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product [LiteratureReference:113798] DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. [LiteratureReference:170767] Domains in the SPT5 protein that modulate its transcriptional regulatory properties [LiteratureReference:170711] Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element [LiteratureReference:113794] Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. [LiteratureReference:170766] HIV-1 infection and regulation of Tat function in macrophages [LiteratureReference:170773] Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro [LiteratureReference:170692] Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor [LiteratureReference:170758] NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation [LiteratureReference:167724] Tackling Tat [LiteratureReference:170763] Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription [LiteratureReference:167818] Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Tat-mediated elongation of the HIV-1 transcript
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-167246
summation	[Summation:167860] The Tat protein is a viral transactivator protein that regul...
updateTrackers	[UpdateTracker:9789224] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v38:[addLiteratureReference, updateContainedPathway] [UpdateTracker:9784457] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v54:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9775346] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v79:[updateContainedRLE] [UpdateTracker:9775152] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v80:[updateIndirectRLE] [UpdateTracker:9787525] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v44:[updateIndirectRLE]

Referrals

(updatedInstance)

[UpdateTracker:9789224] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v38:[addLiteratureReference, updateContainedPathway]
[UpdateTracker:9784457] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v54:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9775346] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v79:[updateContainedRLE]
[UpdateTracker:9775152] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v80:[updateIndirectRLE]
[UpdateTracker:9787525] Update Tracker - [Pathway:167246] Tat-mediated elongation of the HIV-1 transcript - v44:[updateIndirectRLE]

(hasEvent)

[Pathway:R-HSA-167169] HIV Transcription Elongation

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