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Entries
Tat-mediated elongation of the HIV-1 transcript
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compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:167247] Matthews, L, 2005-10-13 20:45:52
dbId
167246
disease
[Disease:1660559] Human immunodeficiency virus infectious disease
displayName
Tat-mediated elongation of the HIV-1 transcript
eventOf
[Pathway:R-HSA-167169] HIV Transcription Elongation - Homo sapiens
figure
[Figure:167487] /figures/TAT_mediated_Elong.jpg
goBiologicalProcess
[GO_BiologicalProcess:80812] positive regulation of viral transcription
hasDiagram
false
hasEHLD
false
hasEvent
[Pathway:R-HSA-167200] Formation of HIV-1 elongation complex containing HIV-1 Tat - Homo sapiens
[Reaction:R-HSA-167181] Addition of nucleotides leads to HIV-1 transcript elongation - Homo sapiens
[Reaction:R-HSA-167192] Pol II elongation complex moves on the HIV-1 template as transcript elongates - Homo sapiens
[Reaction:R-HSA-167197] Separation of elongating HIV-1 transcript from template - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:170749] A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation
[LiteratureReference:167873] A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
[LiteratureReference:170634] Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
[LiteratureReference:113798] DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
[LiteratureReference:170767] Domains in the SPT5 protein that modulate its transcriptional regulatory properties
[LiteratureReference:170711] Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element
[LiteratureReference:113794] Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.
[LiteratureReference:170766] HIV-1 infection and regulation of Tat function in macrophages
[LiteratureReference:170773] Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro
[LiteratureReference:170692] Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor
[LiteratureReference:170758] NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation
[LiteratureReference:167724] Tackling Tat
[LiteratureReference:170763] Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription
[LiteratureReference:167818] Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation
modified
[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name
Tat-mediated elongation of the HIV-1 transcript
relatedSpecies
[Species:164493] Human immunodeficiency virus 1
releaseDate
2006-01-23
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-167246
summation
[Summation:167860] The Tat protein is a viral transactivator protein that regul...
Referrals
(hasEvent)
[Pathway:R-HSA-167169] HIV Transcription Elongation
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