Reactome | Formation of HIV-1 elongation complex containing HIV-1 Tat

Formation of HIV-1 elongation complex containing HIV-1 Tat

Stable Identifier

R-HSA-167200

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        HIV Transcription Elongation (Homo sapiens)
        
        Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
        
        Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)

General

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Formation of HIV-1 elongation complex containing HIV-1 Tat

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This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).

Literature References

PubMed ID	Title	Journal	Year
10757782	Domains in the SPT5 protein that modulate its transcriptional regulatory properties Ivanov, D, Kwak, YT, Guo, J, Gaynor, RB	Mol Cell Biol	2000
7853496	Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor Herrmann, CH, Rice, AP	J Virol	1995
14701750	Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element Fujinaga, K, Irwin, D, Huang, Y, Taube, R, Kurosu, T, Peterlin, BM	Mol Cell Biol	2004
9491887	A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA Wei, P, Garber, ME, Fang, SM, Fischer, WH, Jones, KA	Cell	1998
15564463	Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription Zhou, M, Deng, L, Lacoste, V, Park, HU, Pumfery, A, Kashanchi, F, Brady, JN, Kumar, A	J Virol	2004

Participants

Events

Participates

as an event of

Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)

Inferred From

Formation of RNA Pol II elongation complex (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Cross References

Mondo

0005109

Authored

Matthews, L (2005-07-27)

Rice, AP (2005-07-27)

Created

Matthews, L (2005-10-12)