Reactome | Formation of HIV-1 elongation complex containing HIV-1 Tat

Formation of HIV-1 elongation complex containing HIV-1 Tat

Stable Identifier

R-HSA-167200

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        HIV Transcription Elongation (Homo sapiens)
        
        Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
        
        Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Formation of HIV-1 elongation complex containing HIV-1 Tat

Click the image above or here to open this pathway in the Pathway Browser

This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).

Literature References

PubMed ID	Title	Journal	Year
10757782	Domains in the SPT5 protein that modulate its transcriptional regulatory properties Gaynor, RB, Kwak, YT, Ivanov, D, Guo, J	Mol Cell Biol	2000
7853496	Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor Rice, AP, Herrmann, CH	J Virol	1995
14701750	Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element Peterlin, BM, Irwin, D, Taube, R, Huang, Y, Fujinaga, K, Kurosu, T	Mol Cell Biol	2004
9491887	A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA Wei, P, Jones, KA, Fang, SM, Fischer, WH, Garber, ME	Cell	1998
15564463	Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription Kashanchi, F, Brady, JN, Deng, L, Park, HU, Zhou, M, Pumfery, A, Lacoste, V, Kumar, A	J Virol	2004

Participants

Events

Participates

as an event of

Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)

Inferred From

Formation of RNA Pol II elongation complex (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Matthews, L (2005-07-27)

Rice, AP (2005-07-27)

Created

Matthews, L (2005-10-12)