Reactome | Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex

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Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex Show undefined attributes

authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
catalystActivity	[CatalystActivity:113431] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:167073] Matthews, L, 2005-10-11 08:25:49
crossReference	[DatabaseIdentifier:12020765] Mondo:0005109
dbId	167084
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
edited	[InstanceEdit:165066] Matthews, L, 2005-07-26 23:29:22
eventOf	[Pathway:R-HSA-167152] Formation of HIV elongation complex in the absence of HIV Tat - Homo sapiens
followingEvent	[Reaction:R-HSA-170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex - Homo sapiens [Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex - Homo sapiens
inferredFrom	[Reaction:R-HSA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Homo sapiens
input	11 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-167078] DSIF:NELF:early elongation complex [nucleoplasm] [Complex:R-HSA-112431] P-TEFb complex [nucleoplasm]
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:170692] Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor [LiteratureReference:170763] Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
output	11 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-77088] Cap Binding Complex (CBC) [nucleoplasm] [Complex:R-HSA-167075] HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
precedingEvent	[Reaction:R-HSA-167085] Formation of DSIF:NELF:HIV-1 early elongation complex - Homo sapiens [Reaction:R-HSA-112430] Formation of P-TEFb complex - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-167084
summation	[Summation:170742] The association between Tat, TAR and P-TEFb is believed to b...
updateTrackers	[UpdateTracker:9784473] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v54:[addLiteratureReference] [UpdateTracker:9779207] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v66:[addInput, addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9784473] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v54:[addLiteratureReference] [UpdateTracker:9779207] Update Tracker - [Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - v66:[addInput, addOutput]
(precedingEvent)	[Reaction:R-HSA-170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex [Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex
(hasEvent)	[Pathway:R-HSA-167152] Formation of HIV elongation complex in the absence of HIV Tat
(inferredTo)	[Reaction:R-HSA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex