Reactome | Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex

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Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex

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authored	[InstanceEdit:113400] Gopinathrao, G, 2004-05-06 22:00:00
catalystActivity	[CatalystActivity:113431] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:77054] Buratowski, S, 2003-10-15 15:18:41
dbId	112381
displayName	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
eventOf	[Pathway:R-HSA-112382] Formation of RNA Pol II elongation complex - Homo sapiens
followingEvent	[Reaction:R-HSA-112379] Recruitment of elongation factors to form elongation complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8932788] AFF4 [nucleoplasm] [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-113408] DSIF:NELF:early elongation complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8932787] EAF1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8932790] EAF2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-54257] ELL [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8932918] MLLT1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8932789] MLLT3 [nucleoplasm] [Complex:R-HSA-112431] P-TEFb complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8932796] AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
modified	[InstanceEdit:10306585] Shorser, Solomon, 2020-11-20
name	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
orthologousEvent	[Reaction:R-HSA-167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Homo sapiens [Reaction:R-XTR-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Xenopus tropicalis [Reaction:R-CFA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Canis familiaris [Reaction:R-SSC-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Sus scrofa [Reaction:R-HSA-167191] Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex - Homo sapiens [Reaction:R-MMU-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-77088] Cap Binding Complex (CBC) [nucleoplasm] [Complex:R-HSA-113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
precedingEvent	[Reaction:R-HSA-112430] Formation of P-TEFb complex - Homo sapiens [Reaction:R-HSA-113402] Formation of DSIF:NELF:early elongation complex - Homo sapiens
releaseDate	2004-07-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-112381
summation	[Summation:113428] Cdk-9 is the kinase subunit of P-TEFb that phosphorylates Se...

Referrals

(hasEvent)	[Pathway:R-HSA-112382] Formation of RNA Pol II elongation complex - Homo sapiens
(precedingEvent)	[Reaction:R-HSA-112379] Recruitment of elongation factors to form elongation complex - Homo sapiens