Reactome | P-TEFb complex [nucleoplasm]

Schema > Complex > Entries

P-TEFb complex [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:113431] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-167075] HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - Homo sapiens [Complex:R-HSA-113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] - Homo sapiens [Complex:R-HSA-6814541] RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] - Homo sapiens [Complex:R-HSA-6810225] Initiation factors:CDK7:snRNA gene [nucleoplasm] - Homo sapiens [Complex:R-HSA-167283] HIV-1 paused processive elongation complex [nucleoplasm] - Homo sapiens [Complex:R-HSA-167482] HIV-1 aborted elongation complex after arrest [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Homo sapiens [Reaction:R-HSA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex - Homo sapiens [Reaction:R-HSA-6810234] General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene - Homo sapiens
created	[InstanceEdit:112414] Gopinathrao, G, 2004-05-03 18:16:42
dbId	112431
displayName	P-TEFb complex [nucleoplasm]
hasComponent	[DefinedSet:R-HSA-6807466] CCNT1,CCNT2,CCNK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-51801] CDK9 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-112431] P-TEFb complex [nucleoplasm] - Mus musculus [Complex:R-RNO-112431] P-TEFb complex [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-112431] P-TEFb complex [nucleoplasm] - Canis familiaris [Complex:R-BTA-112431] P-TEFb complex [nucleoplasm] - Bos taurus [Complex:R-SSC-112431] P-TEFb complex [nucleoplasm] - Sus scrofa [Complex:R-DRE-112431] P-TEFb complex [nucleoplasm] - Danio rerio [Complex:R-XTR-112431] P-TEFb complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-112431] P-TEFb complex [nucleoplasm] - Gallus gallus [Complex:R-DME-112431] P-TEFb complex [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-112431] P-TEFb complex [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-112431] P-TEFb complex [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-112431] P-TEFb complex [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SCE-112431] P-TEFb complex [nucleoplasm] - Saccharomyces cerevisiae
literatureReference	[LiteratureReference:6807465] P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA
maxDepth	3
memberOf	[DefinedSet:R-HSA-2176485] CDK8:CCNC/ CDK9:CCNT [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:6807468] May, Bruce, 2015-11-02
name	P-TEFb complex
producedByEvent	[Reaction:R-HSA-112430] Formation of P-TEFb complex - Homo sapiens [Reaction:R-HSA-113429] Elongating transcript encounters a lesion in the template - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-112431
updateTrackers	[UpdateTracker:9893269] Update Tracker - [Complex:112431] P-TEFb complex [nucleoplasm] - v55:[addLiteratureReference, add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9893269] Update Tracker - [Complex:112431] P-TEFb complex [nucleoplasm] - v55:[addLiteratureReference, add_removeHasComponent]
(output)	[Reaction:R-HSA-113429] Elongating transcript encounters a lesion in the template [Reaction:R-HSA-112430] Formation of P-TEFb complex
(activeUnit)	[Requirement:9685236] Requirement by 'RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]'
(input)	[Reaction:R-HSA-6810234] General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene [Reaction:R-HSA-112381] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex [Reaction:R-HSA-167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
(hasComponent)	[Complex:R-HSA-6814541] RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] [Complex:R-HSA-6810225] Initiation factors:CDK7:snRNA gene [nucleoplasm] [Complex:R-HSA-167283] HIV-1 paused processive elongation complex [nucleoplasm] [Complex:R-HSA-113722] Aborted elongation complex after arrest [nucleoplasm] [Complex:R-HSA-167482] HIV-1 aborted elongation complex after arrest [nucleoplasm] [Complex:R-HSA-167286] HIV-1 arrested processive elongation complex [nucleoplasm] [Complex:R-HSA-167081] HIV-1 processive elongation complex [nucleoplasm] [Complex:R-HSA-113720] Paused processive elongation complex [nucleoplasm] [Complex:R-HSA-113721] Arrested processive elongation complex [nucleoplasm] [Complex:R-HSA-113726] Elongation complex with separated and uncleaved transcript [nucleoplasm] [Complex:R-HSA-113724] Elongation complex prior to separation [nucleoplasm] [Complex:R-HSA-113719] Processive elongation complex [nucleoplasm] [Complex:R-HSA-113426] Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] [Complex:R-HSA-167075] HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] [Complex:R-HSA-6797608] CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] [Complex:R-HSA-6797609] Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm]
(physicalEntity)	[CatalystActivity:113431] protein serine/threonine kinase activity of P-TEFb complex [nucleoplasm]
(hasMember)	[DefinedSet:R-HSA-2176485] CDK8:CCNC/ CDK9:CCNT [nucleoplasm]

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