Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
STING recruits TBK1 and IRF3
Show undefined attributes
Go to Details
authored
[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:437051] cytoplasmic vesicle membrane
created
[InstanceEdit:1834959] Shamovsky, V, 2011-10-26
dbId
1834939
displayName
STING recruits TBK1 and IRF3
edited
[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf
[Pathway:R-HSA-3270619] IRF3-mediated induction of type I IFN - Homo sapiens
followingEvent
[Reaction:R-HSA-2396002] TBK1 is phosphorylated within STING:TBK1:IRF3 complex - Homo sapiens
input
2 ×
[EntityWithAccessionedSequence:R-HSA-166251] IRF3 [cytosol]
[Complex:R-HSA-3134799] STING:STING [cytoplasmic vesicle membrane]
2 ×
[EntityWithAccessionedSequence:R-HSA-166267] TBK1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
[LiteratureReference:933497] Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases
[LiteratureReference:933507] SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
[LiteratureReference:1834930] STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
[LiteratureReference:2395975] Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
[LiteratureReference:2408386] Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
[LiteratureReference:2396006] STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
[LiteratureReference:2408415] ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
[LiteratureReference:2408479] The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
[LiteratureReference:8862413] NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
STING recruits TBK1 and IRF3
output
[Complex:R-HSA-1834956] STING:TBK1:IRF3 [cytoplasmic vesicle membrane]
precedingEvent
[Reaction:R-HSA-1834951] IFI16 binds cytosolic dsDNA - Homo sapiens
[BlackBoxEvent:R-HSA-2396009] STING binds c-di-GMP - Homo sapiens
[Reaction:R-HSA-3134822] DDX41 binds viral dsDNA - Homo sapiens
[Reaction:R-HSA-3134800] STING dimerization - Homo sapiens
[BlackBoxEvent:R-HSA-3244643] STING binds cyclic GMP-AMP - Homo sapiens
[Reaction:R-HSA-9013869] DDX41 binds bacterial c-di-AMP, c-di-GMP - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-3245942] Negative regulation by 'TREX1 dimer [endoplasmic reticulum membrane]'
[NegativeRegulation:R-HSA-8862419] Negative regulation by 'NLRC3 [cytosol]'
[PositiveRegulation:9628329] Positive regulation by 'DDX41:DDX41 ligand [cytosol]'
[PositiveRegulation:9628331] Positive regulation by 'MRE11:dsDNA [cytosol]'
[PositiveRegulation:9628325] Positive regulation by 'dsDNA:IFI16 [cytosol]'
[PositiveRegulation:9628330] Positive regulation by 'DNA-PK:microbial dsDNA [cytosol]'
[PositiveRegulation:9628332] Positive regulation by 'DDX41:c-di-AMP, c-di-GMP [cytosol]'
[PositiveRegulation:9628328] Positive regulation by 'STING:c-di-GMP [cytoplasmic vesicle membrane]'
[PositiveRegulation:9628327] Positive regulation by 'STING:cGAMP [cytoplasmic vesicle membrane]'
regulationReference
[RegulationReference:9642392] Negative regulation by 'TREX1 dimer [endoplasmic reticulum membrane]' The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
relatedSpecies
[Species:5689680] Human herpesvirus 1
[Species:2671785] Vaccinia virus
[Species:164493] Human immunodeficiency virus 1
[Species:8875362] Listeria monocytogenes
[Species:5229092] Hepatitis B virus
releaseDate
2013-06-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2422404] D'Eustachio, P, 2012-07-18
[InstanceEdit:2453959] Jin, Lei, 2012-08-18
[InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1834939
summation
[Summation:1834950] In dsDNA-stimulated human and mouse cells TBK1 has been show...
Referrals
(hasEvent)
[Pathway:R-HSA-3270619] IRF3-mediated induction of type I IFN
(precedingEvent)
[Reaction:R-HSA-2396002] TBK1 is phosphorylated within STING:TBK1:IRF3 complex
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text