Reactome | TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

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TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-RNO-2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Rattus norvegicus [Complex:R-RNO-2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] - Rattus norvegicus [Complex:R-RNO-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-2201338] TRAF3 binds TICAM1:activated TLR4 complex - Rattus norvegicus [Reaction:R-RNO-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 - Rattus norvegicus [Reaction:R-RNO-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Rattus norvegicus [Reaction:R-RNO-936985] Activated TLR4:TICAM1 recruits TRAF6 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10116875
displayName	TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-RNO-166170] Ticam1 [cytosol] [Complex:R-RNO-166163] TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Homo sapiens
maxDepth	5
memberOf	[CandidateSet:R-RNO-2569052] TRIF:activated TLR4 [endosome membrane] - Rattus norvegicus
name	TICAM1:TRAM:TLR4:LY96:LPS:CD14
producedByEvent	[Reaction:R-RNO-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) - Rattus norvegicus [Reaction:R-RNO-937075] Phosphorylated TAK1 leaves activated TLR receptor complex - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-166172
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-RNO-937075] Phosphorylated TAK1 leaves activated TLR receptor complex [Reaction:R-RNO-166175] TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1)
(input)	[Reaction:R-RNO-2201338] TRAF3 binds TICAM1:activated TLR4 complex [Reaction:R-RNO-2559568] SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 [Reaction:R-RNO-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 [Reaction:R-RNO-936985] Activated TLR4:TICAM1 recruits TRAF6
(hasComponent)	[Complex:R-RNO-2201339] TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-RNO-2213008] K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-RNO-2569054] RIP3:TICAM1:activated TLR4 [endosome membrane] [Complex:R-RNO-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-RNO-168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-RNO-2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] [Complex:R-RNO-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Complex:R-RNO-2559578] SARM:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-RNO-936976] TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-RNO-936965] K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(hasMember)	[CandidateSet:R-RNO-2569052] TRIF:activated TLR4 [endosome membrane]
(inferredTo)	[Complex:R-HSA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

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