Reactome | K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

Schema > Complex > Entries

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] Show undefined attributes

compartment	[Compartment:74700] endosome membrane
componentOf	[Complex:R-HSA-937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Homo sapiens
created	[InstanceEdit:937009] Shamovsky, V, 2010-08-25
dbId	937016
displayName	K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-937021] K63polyUb-RIPK1 [cytosol] [Complex:R-HSA-166172] TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:171907] endosome lumen
inferredTo	[Complex:R-MMU-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Mus musculus [Complex:R-RNO-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Rattus norvegicus [Complex:R-CFA-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Canis familiaris [Complex:R-BTA-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Bos taurus [Complex:R-SSC-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Sus scrofa [Complex:R-GGA-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Gallus gallus
literatureReference	[LiteratureReference:936978] Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif [LiteratureReference:433849] Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
maxDepth	6
modified	[InstanceEdit:9014318] Shamovsky, Veronica, 2017-07-28
name	K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 activated TLR4:TRIF:K63pUb-RIP1
negativelyRegulates	[NegativeRegulation:R-HSA-2569044] Negative regulation by 'K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'
producedByEvent	[Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-937016
updateTrackers	[UpdateTracker:9875297] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v44:[updateContainedComponent] [UpdateTracker:9873076] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent] [UpdateTracker:9872279] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v41:[add_removeCompartment, add_removeHasComponent, modifyName, removeSpecies, updateContainedComponent] [UpdateTracker:9871358] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9890443] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v52:[updateContainedComponent] [UpdateTracker:9892703] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v54:[updateContainedComponent] [UpdateTracker:9897731] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v62:[add_removeHasComponent, modifyName, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9875297] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v44:[updateContainedComponent] [UpdateTracker:9873076] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v42:[addLiteratureReference, modifyName, updateContainedComponent] [UpdateTracker:9872279] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v41:[add_removeCompartment, add_removeHasComponent, modifyName, removeSpecies, updateContainedComponent] [UpdateTracker:9871358] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v39:[updateContainedComponent] [UpdateTracker:9890443] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v52:[updateContainedComponent] [UpdateTracker:9892703] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v54:[updateContainedComponent] [UpdateTracker:9897731] Update Tracker - [Complex:937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - v62:[add_removeHasComponent, modifyName, removeLiteratureReference]
(hasComponent)	[Complex:R-HSA-937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
(input)	[Reaction:R-HSA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1
(output)	[Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex
(regulator)	[NegativeRegulation:R-HSA-2569044] Negative regulation by 'K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'

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