Reactome | First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal

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First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
catalystActivity	[CatalystActivity:937066] protein serine/threonine kinase activity of IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643512] protein serine/threonine kinase activity of IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane] IRAK-4: a novel member of the IRAK family with the properties of an
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:166116] de Bono, B, 2005-08-18 14:00:28
dbId	166119
displayName	First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-166284] Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-937018] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:TIRAP:activated TLR [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165891] IRAK-4: a novel member of the IRAK family with the properties of an [LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
orthologousEvent	[Reaction:R-GGA-434047] phosphorylation of IRAK2 by activated IRAK4 - Gallus gallus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-166118] p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
precedingEvent	[Reaction:R-HSA-166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - Homo sapiens
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166119
summation	[Summation:169775] First, IRAK1 is phosphorylated at Thr209 by IRAK4. This resu...
updateTrackers	[UpdateTracker:9788181] Update Tracker - [Reaction:166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788181] Update Tracker - [Reaction:166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-HSA-166284] Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP

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