Reactome | Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP

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Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
catalystActivity	[CatalystActivity:937069] protein serine/threonine kinase activity of p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:166283] de Bono, B, 2005-08-23 10:48:00
dbId	166284
displayName	Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-166286] Multiple IRAK1 autophosphorylation steps - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-166118] p-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-166281] pp-IRAK1:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
precedingEvent	[Reaction:R-HSA-166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal - Homo sapiens
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166284
summation	[Summation:169777] Second, Thr387 in the activation loop is phosphorylated, lea...

Referrals

(hasEvent)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
(precedingEvent)	[Reaction:R-HSA-166286] Multiple IRAK1 autophosphorylation steps

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