Reactome | First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal

First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal

Stable Identifier

R-HSA-166119

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Chlamydia trachomatis, Neisseria meningitidis serogroup B

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal

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First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.

Literature References

PubMed ID	Title	Journal	Year
14625308	Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C	J Biol Chem	2004
11960013	IRAK-4: a novel member of the IRAK family with the properties of an Wesche, H, Li, S, Fontana, EJ, Strelow, A	Proc Natl Acad Sci U S A	2002