Reactome | IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex

Schema > Reaction > Entries

IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:166092] de Bono, B, 2005-08-17 10:27:50
dbId	166091
displayName	IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
edited	[InstanceEdit:2562589] Shamovsky, V, 2012-11-06
eventOf	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex - Homo sapiens [Reaction:R-HSA-166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal - Homo sapiens
input	4 × [DefinedSet:R-HSA-937023] IRAK1, IRAK2 [cytosol] [Complex:R-HSA-937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:165888] A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in toll/IL-1R-induced inflammatory [LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity [LiteratureReference:450125] IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination [LiteratureReference:570877] Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control [LiteratureReference:2428843] Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha [LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
orthologousEvent	[Reaction:R-GGA-433864] IRAK2 binds to the IRAK4 accociated with the complex of the activated TLR : TIRAP : MyD88 - Gallus gallus
output	[Complex:R-HSA-166100] IRAK1/or IRAK2:p-IRAK4:MyD88 oligomer:TIRAP:activated TLR [plasma membrane]
precedingEvent	[Reaction:R-HSA-937022] IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP - Homo sapiens
relatedSpecies	[Species:180800] Neisseria meningitidis serogroup B [Species:181384] Chlamydia trachomatis
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30 [InstanceEdit:2603254] Napetschnig, Johanna, 2012-11-16
revised	[InstanceEdit:937065] Shamovsky, V, 2010-08-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-166091
summation	[Summation:2586631] IRAK1 is recruited to the TLR complex through binding with I... [Summation:446680] IRAK2 has been implicated in IL1R and TLR signaling by the o...
updateTrackers	[UpdateTracker:9788381] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v42:[addLiteratureReference] [UpdateTracker:9782066] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v59:[modifyText] [UpdateTracker:9788128] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v43:[addLiteratureReference, add_removeSummation] [UpdateTracker:9789735] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v37:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788381] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v42:[addLiteratureReference] [UpdateTracker:9782066] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v59:[modifyText] [UpdateTracker:9788128] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v43:[addLiteratureReference, add_removeSummation] [UpdateTracker:9789735] Update Tracker - [Reaction:166091] IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex - v37:[modifyText]
(precedingEvent)	[Reaction:R-HSA-937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex [Reaction:R-HSA-166119] First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
(hasEvent)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane

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