Reactome | First, IRAK1 is phosphorylated at Thr209 by IRAK4. This resu...

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created	[InstanceEdit:169774] de Bono, B, 2005-12-06 15:39:32
dbId	169775
displayName	First, IRAK1 is phosphorylated at Thr209 by IRAK4. This resu...
literatureReference	[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
modified	[InstanceEdit:2586668] Shamovsky, V, 2012-11-16
schemaClass	Summation
text	First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.

(summation)

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